Peripheral nerve conduits: technology update
نویسندگان
چکیده
منابع مشابه
Peripheral nerve conduits: technology update
Peripheral nerve injury is a worldwide clinical problem which could lead to loss of neuronal communication along sensory and motor nerves between the central nervous system (CNS) and the peripheral organs and impairs the quality of life of a patient. The primary requirement for the treatment of complete lesions is a tension-free, end-to-end repair. When end-to-end repair is not possible, periph...
متن کامل3D-engineering of Cellularized Conduits for Peripheral Nerve Regeneration
Tissue engineered conduits have great promise for bridging peripheral nerve defects by providing physical guiding and biological cues. A flexible method for integrating support cells into a conduit with desired architectures is wanted. Here, a 3D-printing technology is adopted to prepare a bio-conduit with designer structures for peripheral nerve regeneration. This bio-conduit is consisted of a...
متن کاملDesign of barrier coatings on kink-resistant peripheral nerve conduits
Here, we report on the design of braided peripheral nerve conduits with barrier coatings. Braiding of extruded polymer fibers generates nerve conduits with excellent mechanical properties, high flexibility, and significant kink-resistance. However, braiding also results in variable levels of porosity in the conduit wall, which can lead to the infiltration of fibrous tissue into the interior of ...
متن کاملBiomaterials for the development of peripheral nerve guidance conduits.
Currently, surgical treatments for peripheral nerve injury are less than satisfactory. The gold standard of treatment for peripheral nerve gaps >5 mm is the autologous nerve graft; however, this treatment is associated with a variety of clinical complications, such as donor site morbidity, limited availability, nerve site mismatch, and the formation of neuromas. Despite many recent advances in ...
متن کاملPreclinical evaluations of acellular biological conduits for peripheral nerve regeneration
Various types of natural biological conduits have been investigated as alternatives to the current surgical standard approach for peripheral nerve injuries. Autologous nerve graft, the current gold standard for peripheral nerve damage, is limited by clinical challenges such as donor-site morbidity and limited availability. The purpose of this study was to evaluate the efficacy of using acellula...
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ژورنال
عنوان ژورنال: Medical Devices: Evidence and Research
سال: 2014
ISSN: 1179-1470
DOI: 10.2147/mder.s59124